Table 1

MSI, hMLH1 mutations, expression, and methylation status in human colorectal cancer cell lines

Cell lineMSIhMLH1 mutationhMLH1 expressionMethylation in different regions (%)a
AbBcCdDe
SW1116wild typef+62000
HCT8+57000
Colo201wild typef+60000
Colo320wild typef+55000
RW2982+61000
RW7213+57000
H498+59000
VACO411+64000
VACO10P+60000
CaCo2wild typef+67000
SW1463+40000
HRT18+54000
HT29wild typef+353700
SW620wild typef+241000
LS123+362400
LS174T+exon 4, codon 117, ACG to ATG, Thr to Metg+451100
HCT116+exon 9, codon 252, TCA to TAA, Ser to Stoph,i+62000
C1a+exon 5, codon 129, AGT to GGT, Ser to Glyg958210089
SW48+wild typef,j989610093
VACO5+wild typef,i,j9896100100
VACO6+wild typeh,i958010038
RKO+wild typei79829476
C+wild typeg90859879
Lovok+wild typef+60000
  • a The average of methylation percentage of all CpG sites in each region.

  • b From −711 to −577, containing 23 CpG sites.

  • c From −552 to −266, containing 19 CpG sites.

  • d From −248 to −178, containing eight CpG sites.

  • e From −109 to +15, containing seven CpG sites.

  • f Ref. 17 .

  • g Determined in this study.

  • h Ref. 6 .

  • i Ref. 14 .

  • j Ref. 8 .

  • k Lovo shows the expression of truncated RNA (exons 4–8 deletion) of hMSH2 gene.