Table 3

Patterns of LOH observed in 11 lung squamous cell carcinomas and their corresponding histologically normal epithelium, preneoplasias, and CIS lesions

LOHHistologic categories
3p9p218p21–23Normal and mildly abnormal (n = 27)Dysplasia (n = 15)CIS (n = 12)Invasive carcinoma (n = 11)Total
13 (48%)6 (40%)0019
+7 (26%)0007
++3 (11%)0003
+2 (7%)0002
+00000
++2 (7%)4 (27%)4 (33%)2 (18%)12
++00000
+++05 (33%)8 (67%)9 (82%)22