Table 2

Papillomas arising in p21WAF1-deficient mice do not demonstrate increased frequency of malignant conversion

p21WAF1 genotype% mice with papillomasMaximum no. of papillomas observed% mice with carcinomasaConversion frequency (no. of carcinomas/maximum no. of papillomas × 100)
Experiment 1b
 +/+566111 (19)3.3
 +/−7621720 (54)5.1 [p = 0.74]c
 −/−8117427 (30)4.6 [p = 1.00]
Experiment 2b
 +/+100757 (15)1.3
 +/−829727 (22)6.2 [p = 0.14]
 −/−1009718 (17)3.1 [p = 0.63]
  • a Number of mice with carcinomas/tumor-bearing mice × 100; number in parentheses indicates maximum number tumor bearing mice in each genotype (mice at risk).

  • b Mice in experiments 1 and 2 were 6–10 weeks and 5– 7 Embedded Image months of age, respectively, at time of initial treatment.

  • c Comparison of conversion frequency in p21WAF1 (+/+) versus genotype shown (two-tailed P from Fisher’s exact test).