Table 1

Ap sensitivity and cell cycle arrest

Percentage of cells in S phaseb
Cell lineAp IC50m)apre-Apcpost-Ap (IC50)d
MMR proficient cells
 A27801.930.3 ± 2.32.9 ± 0.6
 cp70-ch33.138.5 ± 2.13.2 ± 1.1
MMR-deficient cells
 A2780-cp702.437.0 ± 3.13.0 ± 1.3
 cp70-ch22.134.2 ± 2.22.5 ± 0.6
  • a The concentration at which a 50% survival of clonogenic cells is seen after a 24-h exposure to Ap.

  • b The percentage of cells in the S-phase fraction is calculated from the number of BrdUrd-positive cells expressed as a percentage of total cells. Errors are SEs of the mean.

  • c The percentage of cells in S phase at time Ap exposure was begun.

  • d The percentage of cells in S phase after a 24-h exposure to Ap at the IC50 concentration.