Table 1

Tumor development in untreated ARF−/− and ARF+/− mice

Case no.SexWeek of onsetTumor type
ARF−/−
1M8Salivary gland carcinoma
2M9Sarcomaa
3F11Spinal cord neural sheath tumor
4F14Sarcomaa
5M16Sarcomaa
6M16Lymphoma
7M16Sarcomaa
8M16Sarcomaa
9M16Osteogenic sarcoma
10F17Thymoma
11M18Sarcomaa
12M18Glioma
13F18Sarcomaa
14M18Glioma
15F20Glioma
16F20Lymphoma
17M20Sarcomaa
18M22Sarcomaa
19M24Sarcomaa
20F26Sarcomaa
21F34T-cell lymphoma
22F36Lymphoma
23F36Lymphoma
24F40Sarcoma
25F40T-cell lymphoma
26F40Squamous cell carcinoma
27M40Squamous cell carcinoma
28F44T-cell lymphoma
29F53Pulmonary adenocarcinoma
30F56Lymphoma
31F60Hemangiosarcoma
32F60Sarcomaa
33M61Lymphoma
34M77Poorly differentiated carcinoma, probably pancreatic
35F79Pulmonary adenocarcinoma
ARF+/−
1M24Myelofibrosis
2F44Sarcomaa
3F60B-cell lymphoma
4F64Lymphangioma
5F68Pulmonary adenocarcinoma
6M76Squamous cell carcinoma
7F84Lymphoma
8M84Hemangioma
9M88B-cell lymphoma
10F90Sarcoma and hepatic angioma
11F98Mammary adenocarcinoma
12F116Hemangioma
  • a Sarcomas were poorly differentiated spindle cell tumors of no specified type, most reminiscent of fibrosarcoma.