Table 2

Tumor frequency in ARF-null animals

GenotypeTreatmentTumor typeIncidence
ARF−/−NoneSarcomas15 (43%)
 Poorly differentiated13
 Osteogenic sarcoma1
 Hemangiosarcoma1
Lymphoid malignancies10 (29%)
 Lymphoma9
 Thymomaa1
Carcinoma6 (17%)
 Squamous cell carcinoma2
 Pulmonary adenocarcinoma2
 Salivary gland carcinoma1
 Poorly differentiated (pancreatic?)1
Tumors of the nervous system4 (11%)
 Gliomas3
 Nerve sheath tumor, spinal cord1
X raySarcomas, poorly differentiated4
Lymphoma1
Meningeal tumor1
DMBASquamous cell carcinoma10
 + lymphoma1
 + sarcoma and adnexal tumor1
 + sarcoma and lymphoma1
 + sarcoma2
Sarcomas, poorly differentiated3
 + adnexal tumor1
ARF+/−NoneLymphomas3
Hemangiomas3
Sarcomas, poorly differentiated2
Lymphangioma1
Squamous cell carcinoma1
Pulmonary adenocarcinoma1
Mammary adenocarcinoma1
Myelofibrosis1
X raySarcomas, poorly differentiated2
Lymphoma1
Mammary carcinoma1
DMBASquamous cell carcinoma3
Pulmonary adenocarcinoma1
Nerve sheath tumor, spinal cord1
  • a Thymoma with a possible carcinomatous component.