Table 1

Defining the relative potency and selectivity of the panel of biochemical inhibitors used in the study [IC₅₀ (μm) of the inhibitors on the basis of publications reported previously]

	5-LOX	FLAP	12-LOX	15-LOX	COX-1	COX-2	References
AA861	4.0^a	ND^b					15
MK886	ND	0.25^c	ND	ND	ND	ND	16
Baicalein		ND	0.12^c		>100^c	>100^c	17
CDC	1.89^c	ND	0.063^c	3.33^c			18
NDGA	0.2^c	ND	30^c	30^c	100^c	100^c	19
ETYA	10^c	ND	0.3^c	0.2^c	8^c	8^c	20
ASA		ND			10^c	50^c	21
Indomethacin	100^c	ND	100^c	100^c	5^c	100^c	21
NS398		ND			100^c	3.8^c	22

a Purified enzyme.
b ND, not determined.
c Cell suspension.