Table 1

Defining the relative potency and selectivity of the panel of biochemical inhibitors used in the study [IC50m) of the inhibitors on the basis of publications reported previously]

5-LOXFLAP12-LOX15-LOXCOX-1COX-2References
AA8614.0aNDb 15
MK886ND0.25cNDNDNDND 16
BaicaleinND0.12c>100c>100c 17
CDC1.89cND0.063c3.33c 18
NDGA0.2cND30c30c100c100c 19
ETYA10cND0.3c0.2c8c8c 20
ASAND10c50c 21
Indomethacin100cND100c100c5c100c 21
NS398ND100c3.8c 22
  • a Purified enzyme.

  • b ND, not determined.

  • c Cell suspension.