Table 3

Effects of Se-methylselenocysteine and methylseleninic acid on apoptosis in TM2H and TM12 cells

TreatmentTM2H cellsa (%)TM12 cellsa (%)
None2.0 ± 0.3b8.5 ± 0.7b
25 μm3.0 ± 0.5b,c9.0 ± 0.7b
50 μm4.5 ± 0.6c15.0 ± 1.3c
None2.2 ± 0.5b9.2 ± 0.4b
Methylseleninic acid
2.5 μm8.5 ± 0.5c24.5 ± 0.9c
5 μm12.8 ± 1.0d33.5 ± 1.2d
  • The data are expressed as a percentage of acridine orange- and ethidium bromide-stained apoptotic cells, mean ± SE (n = 6 replicates).

  • b,c,d The data were analyzed by factorial analysis of variance. The method of post hoc multiple comparisons was used to determine statistical significance among all treatment conditions (i.e., dose and type of selenium compound) within a cell line. Values that do not share common superscripts are significantly different from each other (P < 0.05).