Table 6

Ability of methylseleninic acid to replete glutathione peroxidase and thioredoxin reductase activities in liver of selenium-deficient ratsa

GroupGlutathione peroxidase (%)Thioredoxin reductase (%)
Selenium-adequate control rats100100
Selenium-deficient rats1.5 ± 0.15.3 ± 0.3
Repletion with
Sodium selenite at 0.1 ppm Se (positive control)97.5 ± 5.894.7 ± 6.6
Methylseleninic acid at
0.05 ppm Se56.1 ± 4.251.3 ± 3.9
0.1 ppm Se77.8 ± 6.372.7 ± 6.1
0.2 ppm Se106.2 ± 6.898.4 ± 7.5
  • The data are expressed as percentages of control activity in the liver of rats fed a selenium-adequate diet (set as 100%). n = 8 rats/group.