Table 1

Fhit protein expression in colorectal carcinomas

The following trends were observed: the proportion of tumors with reduced expression increased with decreasing differentiation (χ2 = 5.76, df = 1, P = 0.016); the proportion of tumors with reduced expression increased in tumors with metastases (Dukes’ stage C + D) compared with tumors without metastases (Dukes’ stage A + B; χ2 = 3.68, df = 1, P = 0.055). There was a lack of association of differentiation with Fhit expression (P = 0.1204, Fisher’s exact test); and of Dukes’ stage with Fhit expression (P = 0.4512, Fisher’s exact test).

Fhit protein expressionTotal
PreservedIntermediateReduced or absent
Differentiationa
WD71210
MD25133068
PD1056
Dukes’ stage
A1541231
B1371232
C33915
D2046
Total33143784
  • a WD, well differentiated; MD, moderately differentiated; PD, poorly differentiated.