Table 1

Analysis of the effects of combination therapy on clonogenicity of K562 leukemic cells

The table presents a comparison of the predicted clonogenicity (based on an assumption that the activities are additive) and the experimentally observed clonogenicity after combination therapy.

CombinationPredicted clonogenicity (relative to a baseline clonogenicity of 1X)Observed clonogenicity (relative to a baseline clonogenicity of 1X)
Stathmin inhibition+ TAXa0.56 × 0.54 = 0.30X0.13X
Stathmin inhibition+ 5-FU0.56 × 0.63 = 0.35X0.30X
Stathmin inhibition+ DOX0.56 × 0.57 = 0.32X0.35X
  • a TAX, Taxol; DOX, doxorubicin.