Table 2

NS398 inhibition of mesothelial cells and mesothelioma cell linesa

CellCell typeSolvent blank100 μm NS398% inhibition
CHTN 18650Primary8.7 × 10 (±1.0)7.55 ± 10 (±1.3)13
VAMT-1MM2.53 × 10 (±0.36)7.53 × 10 (±0.45)70
M10KMM6.26 × 10 (±3.0)2.95 × 10 (±2.9)53
M14KMM1.67 ± 10 (±2.0)6.91 × 10 (±2.8)59
M33KMM1.33 ± 10 (±0.13)5.0 × 105 (±0.52)63
  • Cells were seeded in triplicate at 5 × 104 cells/60-mm dish and treated with 100 μm NS398 as described in “Materials and Methods.” At 6 days, all dishes were trypsinized, and viable cells were counted. Data show the average cell number ± SD.