Table 2

Summary of significant DNA copy number changes in GISTs

DNA copy number changes seen in primary malignant and metastatic tumors were compared to benign lesions. Ps are shown in parentheses. Ps shown in italics indicate comparison between metastatic and primary malignant tumors. Gains are indicated with + and losses with āˆ’.

Chromosomal regionBenign GISTMalignant GISTMetastatic GIST
8q+8%33% (<0.001)57% (<0.001), (<0.05)
17q+025% (<0.05)43% (<0.001), (<0.05)
20q+011% (<0.001)26% (<0.001), (<0.05)
5p+031% (<0.001)29% (<0.001)
9pāˆ’036% (<0.001)63% (<0.001), (<0.05)
13qāˆ’8%36% (<0.05)46% (<0.001)