Table 1

Frequency of liver metastasis 10 weeks after intrasplenic injection of HT-29 cells in nude mice

Liver foci larger than 0.1 mm in diameter were not observed in a group of animals treated with 200 mg cimetidine/kg/day.

No. of cells injectedControl (saline)Cimetidine (mg/kg/day)
1050200
Experiment 11 × 1015 /17 (88%)6 /9 (67%)5 /9 (56%)0 /9 (0%)a
Experiment 21 × 1015 /17 (88%)8 /10 (80%)4 /9 (44%)b4 /10 (40%)b
  • P < 0.001.

  • P < 0.05 (compared with control).