Table 2

DDD of down-regulated genes in tumors

Hits showing >10-fold differences in normal organ-derived cDNA library in comparison with tumor-derived and other organ-derived libraries were compiled. The hits are classified as shown in Table 2 <$REFLINK> .4

NameHs.#BrCoLuOvPaPr
Enzymes (N = 7)
Creatine kinase, brain17372410
TIMP 1a583110
Myosin light kinase21158213
Superoxide dismutase 217778120
Aldo-keto reductase7818316
Amylase, α 2A7573315
Elastase 3B18386418
Receptor/surface/membrane (N = 8)
Phospholemman-like9232315
CEA22052914
MHC class I, E18139221
Surfactant C107419
Surfactant A117758234
SB class HC antigen α91415
Surfactant B7630514
CD4416961022
Secretory proteins (N = 9)
HB α 175792121401330
Hb γ A182167121122
Albumin75442295810
Placental lactogen7598439
Hb β15537611
TGFBI11878712
CTGF7551117
PLAB11657721
Interleukin 8624301
Ribosomal proteins (N = 6)
L915785016
L178220211
L2118410815
L2323451815
L37A18410923
S1912670711
Binding proteins (N = 13)
Myosin961535
Crystallin α B194019
SNC73 protein322251012
Galectin 4530218
Myosin92920
Pleckstrin7743670
Actin, β18095214
α-2-Macroglobulin7456113
EIF4A112967310
IGFBP510339183
Transgelin7577714
Karyopherin α 411950011
TYR-MAP-β18223810
Cell adhesion molecules (N = 2)
Fibronectin11816215
Vimentin206412
Immunoglobulins (N = 2)
FCGRT16074111
Ig κ15611010
  • a TIMP, tissue inhibitor of metalloproteinase 1; CEA, carcinoembryonic antigen; HB, hemoglobin; TGFB, transforming growth factor β; PLAB, prostate differentiation factor; SNC73, immunoglobulin heavy constant α 1; EIF, eukaryotic translation initiation factor; IGFBP, insulin-like growth factor-binding protein; TYR-MAP, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein; FCGRT, Fc fragment of IgG receptor.