Table 3

Pharmacokinetic model parameters for control and Es1e mice

A linear four-compartment pharmacokinetic model was fitted to CPT-11 and SN-38 plasma concentrations by maximum-likelihood estimation after administering a single retro-orbital dose of 10 mg/kg CPT-11 to control and Es1e mice.

Pharmacokinetic parameterControlEs1e
CPT-11
AUC0→∞ (ng/ml·h)10901341
k13 (h)4.170.89
CL (liters/h/m)244.7138.6
SN-38
AUC0→∞ (ng/ml·h)11860.2
k30 (h)27.411.4