Table 1

Characteristics of SCLC and NSCLC cell linesa

SCLCSexMatched BL heterozygosityFALAverage size of LOH (no. of markers)No. of whole chromosome lossesNo. of breakpointsNo. of MAsbNo. of LOH hot spotsNSCLCSubtypecSexMatched BL heterozygosityFALAverage size of LOH (no. of markers)No. of whole chromosome lossesNo. of breakpointsNo. of MAsbNo. of LOH hot spots
H128M85%44%5.64242416H1395ADF78%36%7.4219520
H209M81%22%6.1116913H1648ADM83%40%5.9321527
H289F77%43%7.7611518H1819ADF81%45%4.9242934
H1184M77%33%5.9223617H1993ADF76%34%5.3128721
H1450M75%28%5.4221512H2009ADF77%41%4.92371429
H1607M78%45%5.2333622H2087ADM77%40%6.14201022
H1672M80%36%9.2312316H2122ADF78%29%6.94121116
H1963M84%12%4.3013210H2347ADF79%17%7.319413
H2107M83%25%4.4221117H2882NSF82%63%5.3821436
H2141M76%28%5.9311616H2887NSM77%35%3.6522822
H2171M77%48%6.4617222HCC44ADF80%40%6.3418222
H2195M78%38%5.8220417HCC78ADM78%1%1.00432
HCC33M83%25%5.3119115HCC193ADF77%23%7.248217
HCC970M77%42%6.0711223HCC515ADF77%34%5.7321620
HCC827ADF81%52%4.7138230
Average79.4%34%5.9318517HCC366ASF75%29%3.82251117
SD3.1%11%1.32664H1770NEM81%31%7.8211112
H2052MEM79%32%5.7320020
H2126LCM77%49%5.5527330
HCC15SQM84%40%4.6718423
HCC95SQM77%43%7.4318429
HCC1171LCM79%35%4.8320119
Average78.7%36%5.5420522
SD2.4%12%1.63948
Pd0.50.60.40.40.60.90.012
  • a Sizes of LOH regions for individual tumors are measured as the number of contiguous markers with LOH, including intervening NI markers between flanking regions of LOH. Whole chromosome losses are not included in these calculations. Breakpoints are defined as junctions between LOH and HET (with or without intervening NIs) for individual samples. Hot spots are minimal regions of frequent (>35%) LOH.

  • b 105 markers have 1 MA; 23 markers have 2 MAs; 7 markers have 3 MAs (D1S450, D6S1574, D6S309, D6S470, D17S1868, D20S178, and D22S283); and 2 markers have 4 MAs (D16S3136 and D20S178).

  • c AD, adenocarcinoma; AS, adenosquamous cell; LC, large cell; ME, mesothelioma; NE, neuroendocrine; SQ, squamous cell; NS, not specified.

  • d P for differences between SCLC and NSCLC as measured by Student’s t test.