Table 2

Markers defining the minimal areas of allele loss (hot spots)

SCLCNSCLC
MarkersaLocibFrequency of regional lossCandidate TSGscMarkersLociFrequency of regional lossCandidate TSGs
D1S4681p36.340% p73,TNFR2 D1S468-D1S2697 1p36.12-pter 64% p73, NBL1/DAN, TNFR2
D1S196 1q23 d 82%D1S2071p31.153%
D3S1297-D3S1263 3p25-26 100% VHL D1S206-D1S2521p22-q12d52%
D3S1266 3p22.3-24 100% TGFBR2, DLC1 D1S196/D1S2181q23-24d55%
D3S1289-D3S1566 3p13-p22 100% TGFBR2, MLH1/HNPCC2 D1S2800-D1S28421q41-43d40%
DLC1, PTPG, FHIT, BAP1 D3S1297-D3S13043p25.2-pter50% VHL
D4S412-D4S4194p15-1654%D3S23383p23-25.158%
D4S405-D4S392 4p14-q13 67%D3S1277/D3S12893p21.2-2259% TGFBR2, DLC1,
D4S414-D4S406 4q21-28 79% MLH1/HNPCC2, BAP1
D4S1535-D4S426 4q34-ter 77%D3S13003p14.253% FHIT, PTPG
D5S407-D5S424 5p13-q13 79% DOC2/DAB2 D3S3681-D3S12713p13-q1350%
D5S410-D5S408 5q32-ter 79%D4S4144q21-23d43%
D8S277-D8S2588p21.3-23.150%D4S15354q34-3550%
D9S2869p23d38%D5S471-D5S21155q21.3-3135% MCC, APC, IRF1
D9S1677 9q22.33-32 d 64% PTCH D6S1574-D6S3096p24-terd41%
D10S249 10p15.3 d 89%D6S2926q22.3-23d55%
D10S548/D10S19710p12.3d57%D6S264-D6S2816q26-2748% IGF2R
D10S1686 10q22-23.1 85%D8S277-D8S258 8p21.3-23.1 73% DR5
D11S4046-D11S133811p15.3-15.550%p57KIP2, BE2, HTS1/ST5D9S171 9p21.3-22 79% p16INK4A, p15INK4B, p14 ARF
D13S171-D13S263 13q12-14 93% RB1, BRCA2 D9S1677-D9S2909q22.33-34.1d55% TSC1
D13S285 13q34 d 62% ING1 D9S1826-D9S1589q34d50% TSC1
D15S128-D15S16515q11-13d57%D10S591-D10S18910p15d38%
D15S11715q21-22.2d58%D10S208/D10S19610p11-q11d41%
D16S3136-D16S52016q36% RB2, CDH1 D10S21210q26.13-terd36%
D17S849-D17S921 17p12-ter 93% p53 D11S935-D11S90511p11-1435% WT1, KA11
D18S462-D18S7018q2336%D11S417511q14.3-2145%
D20S11720p13d40%D12S352-D12S36412p12.3-ter45%
D13S175 13q11 d 67%
D13S171-D13S263 13q12-14 62% RB1, BRCA2
D15S12815q11d50%
D15S1007-D15S99415q13-21.1d48%
D15S127-D15S12015q25-terd36%
D16S423-D16S40416p13.3d45% TSC2
D16S515-D16S52016q22-ter45% CDH1
D17S849-D17S1852 17p12-13 86% p53
D18S47818q11.2d59%
D18S462-D18S7018q2357%
D19S209-D19S884 19p13.3 77%
D19S220-D19S42019q12-13.250%
D19S21019q13.33-ter52%
D20S18620p12d50%
D21S1256/D21S191421q2138%
D22S42022q1140% SNF5/INI1, CLTD
D22S42322q1359%
DXS1060-DXS991 Xp-q21 67%
DXS990 Xq22.1 d 67%
  • a Slashes indicate that the minimal region of loss is between the two markers but does not include these markers.

  • b Loci with more than 60% loss are underlined.

  • c Genes in bold represent those that were definitely shown to be abnormal in lung cancer.

  • d Novel sites of frequent allelic loss in lung cancer.