Table 1

HLA-DRB1*0401-binding NY-ESO-1 peptides predicted by the peptide binding algorithm

Peptide binding sequences are provided using single-letter amino acid designation. Peptide binding algorithm (11 , 12) scores for the highest-scoring embedded 9-mer sequences (underlined) are indicated for each peptide evaluated.

NY-ESO-1 peptides: amino acid residuesSequencesAlgorithm score, 0–10Peptides tested in the study
119–143PGVLLKEFTVSGNILTIRLTAADHR+
119–133PGVLLKEFTVSGNIL+
123–137LKEFTVSGNILTIRL+
129–143SGNILTIRLTAADHR+
122–130 LLKEFTVSG 9
126–134 FTVSGNILT 4
132–140 ILTIRLTAA 4
144–169QLQLSISSCLQQLSLLMWITQCFLPV+
147–155 LSISSCLQQ 3
153–161 LQQLSLLMW 3
158–166 LLMWITQCF 6
161–170 WITQCFLPV 3
158–180LLMWITQCFLPVFLAQPPSGQRR+
161–170 WITQCFLPV 3
162–170 FLPVFLAQP 5
166–174 VFLAQPPSG 6
169–177 FLAQPPSGQ 4