Table 1

Effects of celecoxib or piroxicam treatment on plasma thromboxane B2 levels (COX-1 activity)

Drug dose in diet (ppm)Drug in blood (μg/ml)Thromboxane B2 (ng/ml)COX-1 (% control)
A. Early treatment (age 30–80 days)
Control000.338 ± 0.060100
Celecoxib1500.09 ± 0.010.371 ± 0.121
5000.26 ± 0.100.124 ± 0.030
15001.80 ± 0.730.504 ± 0.202
0.333 = mean99
Piroxicam50NDa0.199 ± 0.13457
B. Late treatment (age 55–80 days)
Control001.049 ± 0.329100
Celecoxib1500.10 ± 0.011.083 ± 0.357
5000.25 ± 0.010.229 ± 0.074
15000.70 ± 0.261.031 ± 0.119
0.781 = mean74
Piroxicam500.05 ± 0.020.224 ± 0.13821
  • a ND, not determined.