Table 2

Effects of celecoxib or piroxicam treatment on colon or small intestine tumor multiplicity

Drug dose in diet (ppm)Tumors in small intestineColonTotal%
ProximalMiddleDistal
A. Early treatment (age 30–80 days)
Celecoxib04.7 ± 0.79.0 ± 1.37.3 ± 1.01.5 ± 0.522.4 ± 2.6100
1502.6 ± 0.75.8 ± 1.46.8 ± 1.10.8 ± 0.315.8 ± 2.771
5004.8 ± 0.74.3 ± 0.76.2 ± 0.80.5 ± 0.26.5 ± 1.371
15002.5 ± 0.41.6 ± 0.61.8 ± 0.50.6 ± 0.26.4 ± 1.229
Piroxicam503.7 ± 0.90.9 ± 0.30.8 ± 0.30.6 ± 0.25.2 ± 1.223
B. Late treatment (age 55–80 days)
Celecoxib04.8 ± 0.58.9 ± 1.28.3 ± 0.90.83 ± 0.322.9 ± 1.9100
1504.4 ± 0.56.9 ± 1.35.9 ± 0.90.75 ± 0.418.0 ± 2.279
5005.1 ± 0.76.2 ± 1.14.6 ± 0.70.42 ± 0.216.3 ± 1.871
15002.2 ± 0.44.1 ± 1.12.8 ± 0.52.1 ± 0.511.1 ± 2.048
Piroxicam503.7 ± 1.01.9 ± 0.51.1 ± 0.21.4 ± 0.37.9 ± 1.434