Table 1

Effect of SAHA administration on the body weights and survival of the CWR22-bearing mice

TreatmentInitial body weight (g)aFinal body weight (g)Deaths [days (D) of treatment]
Vehicle (DMSO)26.2 ± 0.5 (n = 8)27.7 ± 0.6 (n = 8)0
25 mg/kg SAHA23.8 ± 0.7 (n = 8)25.5 ± 1.3 (n = 8)0
50 mg/kg SAHA24.8 ± 0.7 (n = 9)25.8 ± 0.7 (n = 8)1 (D20)
100 mg/kg SAHA24.8 ± 0.7 (n = 9)24.0 ± 0.8 (n = 4)5 (D6, D9, D14, D16, and D21)b
  • a All values are presented as the mean ± SE for the surviving animals (n) in each treatment group. Initial and final body weights refer to the weight of the mice at the start of SAHA treatment and the end of the experiment, respectively.

  • b Mice that died in this dose group showed marked weight loss for 1–2 days before death.