Table 1

List of candidate HLA-B7 CTL epitopes for CEAa

AntigenSequencePosition of first residueBIMAS scorebSYFPEITHI scorecCTL activityd
Predicted epitopes
CEAPPTTAKLTI300.818NTe
CEAGPAYSGREI92818NT
CEAYPELPKPSI1413.620NT
CEALPVSPRLQL185/363/541180260/96
CEANPPAQYSWL44280210/96
CEAPPAQYSWLI4430.817NT
CEAIPQQHTQVL63280233/96
Known epitopes
EBNA-6fQPRAPIRPI88112023NT
EBNA-3fRPPIFIRRL2478021NT
RU2-ASgLPRWPPPQLND120026NT
iCE (+1ORF)hSPRWWPTCLND80023NT
  • a In bold type: potential HLA-B7-restricted CTL epitopes for CEA.

  • b Algorithm score obtained using the computer program developed by Parker et al. (20) .

  • c Algorithm score obtained using the computer program developed by Rammensee et al. (21) .

  • d CTL activity is the number of positive CTL cultures in a total of 96 from two blood donors.

  • e NT, not tested; ND, not determined.

  • f CTL epitope described in 22 ,, 23 .

  • g CTL epitope described in 24 .

  • h CTL epitope described in 25 .