Table 1

Peptides predicted to be promiscuous HTL epitopes

Sequence (9-mer core)DR1DR4DR7Rank sumaPeptide namePeptide sequenceb (15–18)mer
ARBRankARBRankARBRank
YVAPLTCSP85.03666.35127.51310HER1124TDGYVAPLTCSPQPE
YVMAGVGSP24.691729.64419.521132HER765KEILDEAYVMAGVGSPYVS
WCMQIAKGM35.48139.561522.72634HER822LLNWCMQIAKGMSYL
WMALESILR13.073020.24645.23238HER883KVPIKWMALESILRRRF
LDEAYVMAG15.18285.422919.771067HER765KEILDEAYVMAGVGSPYVS
IKWMALESI5.07517.332157.56173HER883KVPIKWMALESILRRRF
LSYMPIWKF16.41243.544120.01974HER605KPDLSYMPIWKFPDE
LPTNASLSF2.44668.171710.6518101HER62LTYLPTNASLSFLQD
LTSIISAVV1.78777.02239.5719119HER648ASPLTSIISAVVGIL
  • a Rank sum = DR1 rank + DR4 rank + DR7 rank.

  • b These peptides were selected for synthesis for T-cell studies. The core region is shown underlined.