Table 2

Proliferative responses to HER2/neu peptides

Donora peptidesT-cell responses (SI)b
DR1/11;DR52;DQ5/7DR1/13;DR52;DQ5/7DR4/15;DR51/53;DQ6/7DR7/17;DR52/53;DQ2
TCLcPBMCL-DR1TCLPBMCL-DR1TCLPBMCL-DR4TCLPBMCL-DR7
HER112412F1.1NTd8F1.0NT10B1.3NT7G1.2NT
HER82211C31.3NT3B207.1NT4E117.7NT
7B9.6NT
HER7653B1.1NT8A14.726.99B252.7NT
7D23.5423.3
HER88311A334.3NT8F92.2271.76D143.580.41D22.81.5
2A82.343.27C67.61.91E115.73.5
12F181.3NT
HER60512H1.9385.412B12.218.34A61.0NT
1H200.3NT6B207.4NT
HER623H0.9NT6F114.9484.34E10.3241.5
11F8.7624.05D12.7183.2
HER6481H1.21.0NT8E75.7590.9
  • a Four normal donor volunteers were tested in these experiments (their respective HLA-DR and -DQ alleles are shown).

  • b T-cell proliferative responses are expressed as SI, calculated as described in “Materials and Methods.”

  • c Several TCLs were analyzed for their proliferative responses to peptide presented by either autologous PBMCs or L-cells transfected with individual DR molecules.

  • d NT, not tested.