Table 1

Molecular characteristics of OCs with hypermethylated and unmethylated BRCA1 promoters

Tumor no.BRCA1 methylationBRCA1 protein stainingbBRCA1/2 mutationap53 staining
T853+Not detectedNone+++
T900+Not detectedNone++
T924+Not detectedNone
T925+Not detectedNone+++
T953+Not detectedNone
T955+Not detectedNone
T975+Not detectedNone++
T986+Not detectedNone
T1002+Not detectedNone+
T1008+Not detectedNone+++
T1026+Not detectedNone
T1041+Not detectedNone
T429+None
T921Not detectedNA
T954FaintNA
T856+None+++
T958Not detectedNA++
T859++NA+
T860+NA++
T974+None+++
T980++NA
  • a Tumors were analyzed for the three founder mutations common in Ashkenazi Jews.

  • b IHC staining intensity was scored as: −, +, ++, and +++.

  • c NA, not analyzed. −, negative; +, faint; ++, strong; and +++, intense.