Table 1

Effects of dietary folate intervention on serum folate concentrations, small intestinal and colonic adenomas, and ACF at 3 monthsa

Dietary folate (mg folate/kg diet) 0 2 820
No. of mice10111011
Serum folate (ng/ml)12.1 ± 3.9i39.0 ± 3.4ii56.0 ± 3.9iii49.9 ± 3.5ii, iii
Average no. of small intestinal adenomas/mouse
Duodenal adenomas8.00 ± 1.76.54 ± 1.66.30 ± 1.78.36 ± 1.7
Jejunal adenomas5.40 ± 2.39.36 ± 2.27.40 ± 2.36.18 ± 2.2
Ileal adenomasb11.0 ± 1.6i7.36 ± 1.6i7.30 ± 1.6i2.36 ± 1.6ii
Total adenomas24.4 ± 4.423.3 ± 4.222.0 ± 4.416.9 ± 4.2
Average no. of colonic ACF/ mousec1.30 ± 0.3i0.27 ± 0.3ii0.20 ± 0.3ii0.00 ± 0.3ii
Average no. of colonic adenomas/mouse4.60 ± 0.74.18 ± 0.73.20 ± 0.704.18 ± 0.7
  • a Values are means ± SE. Means with different superscript letters in each row indicate statistical differences at P < 0.05 by Fisher’s least-significance-difference multiple comparison test.

  • b P-linear trend = 0.001.

  • c P-linear trend = 0.05.