Table 3

Effect of lysine coinjection on the kidney uptake of 99mTc-CCMSH in C57 BL/6 mice at 30 min and 1 h after injection (n = 5; % ID/g or % ID)

Tissues (% ID/g)30 min1 h
Group 1aGroup 2Group 1Group 2
Blood2.11 ± 0.771.57 ± 0.591.18 ± 0.471.54 ± 0.53
Heart1.06 ± 0.210.70 ± 0.330.62 ± 0.160.82 ± 0.34
Lungs2.83 ± 0.682.14 ± 0.361.67 ± 0.762.07 ± 0.43
Spleen0.87 ± 0.580.52 ± 0.250.58 ± 0.240.63 ± 0.44
Liver1.67 ± 0.291.48 ± 0.341.47 ± 0.271.60 ± 0.49
Kidney10.35 ± 0.4310.84 ± 1.348.91 ± 1.7211.01 ± 1.78
Pancreas0.68 ± 0.120.36 ± 0.180.38 ± 0.110.52 ± 0.16
Muscle0.74 ± 0.370.34 ± 0.170.46 ± 0.290.35 ± 0.07
% ID
Blood2.86 ± 0.851.88 ± 0.531.56 ± 0.461.96 ± 0.70
Stomach0.25 ± 0.030.62 ± 0.860.32 ± 0.260.76 ± 0.81
Intestine4.60 ± 0.534.78 ± 0.575.09 ± 1.124.47 ± 1.52
Kidney3.21 ± 0.332.66 ± 0.362.49 ± 0.362.74 ± 0.40
Urine65.14 ± 3.8965.98 ± 13.675.12 ± 4.4769.44 ± 12.89
  • a Group 1 received i.p. injections of 20 mg of lysine and after 5 min i.v. injections of a mixture of 99mTc-CCMSH and 25 mg of lysine. Group 2 received i.v. injections of a mixture of 99mTc-CCMSH and 25 mg of lysine only.