Table 4

Biodistribution comparison of 99mTc-CCMSH with or without lysine coinjection in B16/F1 murine melanoma-bearing C57 BL/6 mice at various times after injection (% ID/g or % ID; n = 5)

Tissues (% ID/g)30 min1 h4 h24 h
Lysine (−)Lysine (+)Lysine (−)Lysine (+)Lysine (−)Lysine (+)Lysine (−)Lysine (+)
Tumor12.97 ± 2.3814.08 ± 1.2211.64 ± 1.5411.68 ± 1.559.51 ± 1.9711.32 ± 3.251.38 ± 0.362.59 ± 0.83
Blood3.28 ± 1.091.97 ± 0.271.26 ± 0.151.06 ± 0.490.62 ± 0.210.29 ± 0.270.06 ± 0.030.05 ± 0.03
Heart1.55 ± 0.361.05 ± 0.370.49 ± 0.230.64 ± 0.570.25 ± 0.150.27 ± 0.170.13 ± 0.130.11 ± 0.06
Lungs3.73 ± 0.863.19 ± 0.351.54 ± 0.251.54 ± 0.490.55 ± 0.120.32 ± 0.160.10 ± 0.060.16 ± 0.05
Spleen0.92 ± 0.450.64 ± 0.230.54 ± 0.240.33 ± 0.260.54 ± 0.190.30 ± 0.250.18 ± 0.280.12 ± 0.12
Liver2.36 ± 0.191.44 ± 0.291.79 ± 0.531.03 ± 0.370.65 ± 0.080.63 ± 0.160.06 ± 0.020.14 ± 0.05
Kidney20.60 ± 2.4210.74 ± 2.20a19.71 ± 1.188.85 ± 2.25b14.60 ± 1.884.45 ± 0.62b1.22 ± 0.150.96 ± 0.27
Muscle1.11 ± 0.470.69 ± 0.340.47 ± 0.520.15 ± 0.070.08 ± 0.060.16 ± 0.140.05 ± 0.050.03 ± 0.02
% ID
Blood3.07 ± 0.912.60 ± 0.431.20 ± 0.081.38 ± 0.640.65 ± 0.210.35 ± 0.320.07 ± 0.040.06 ± 0.04
Stomach0.79 ± 0.240.53 ± 0.080.58 ± 0.150.52 ± 0.060.37 ± 0.200.28 ± 0.100.00 ± 0.000.06 ± 0.06
Intestine3.16 ± 0.233.79 ± 0.274.53 ± 0.594.61 ± 0.716.03 ± 1.797.85 ± 1.740.15 ± 0.070.31 ± 0.22
Urine57.48 ± 7.3265.22 ± 3.3667.18 ± 5.9372.81 ± 7.7581.83 ± 2.45c81.84 ± 3.45c98.36 ± 0.51c97.12 ± 1.04c
Uptake ratio of tumor:normal tissue
Tumor:blood4.07.19.211.0 15.339.023.051.8
Tumor:muscle11.720.424.877.8118.870.727.686.0
  • a 0.05 > P > 0.01.

  • b P < 0.01.

  • c Urine + feces.