Table 1

Expression of Cyr61 in breast cancer cell linesa

Cell lineCyr61HRGERInvasive in vitroMetastatic in vivoαvβ3b
MCF-7++++c+/−
T47D++c
BT474++c
MDA-MB-175+/−d+cND
ZR75B+/−d+c
MDA-MB-468++e
SKBR-3++e
MDA-MB-157+++++NDND
MDA-MB-436+++++++++NDND
BT-549++++++++++ND
MDA-MB-231++++++++++++++++
MDA-MB-435++++++++++++++++
HS578T+++++++++++++ND
MCF-7/HRG++++++−/+++++++
  • a − indicates no expression; the number of plus signs indicates the increase in expression.

  • b The αvβ3 integrin expression is based on results from Ref. 19 and our preliminary data. ND, not determined.

  • c Cells require E2 for invasion in vitro and growth in vivo and never metastasize in vivo.

  • d E2 induces expression of HRG.

  • e Cells require ligand (epidermal growth factor or HRG) to invade but never metastasize in vivo.