Table 1

Genes up-regulated by c-Myca

No.Gene nameFunctionRatiob-Serac
c-mycTranscription2.6
1 Cdc2 d Cell cycle3.6
2 cdk regulatory subunit 2 (CKS-2) Cell cycle3.4
3 Proliferating cell nuclear antigen (PCNA) Cell cycle3.2
4 AIM-1 Cell cycle2.7
5 Mitotic feedback protein control protein Cell cycle4.2
6 Adenine nucleotide translocator Apoptosis3.4
7 Proliferating cell-associated mRNA Cell growth2.5
8 JTV-1 protein Cell growth2.6
9 Lens epithelial protein Cell growth3.4
10 rab GDP-dissociation inhibitor β Signaling2.6
11 rhoB Signaling4.0
12 Protein phosphatase-1 γ1 (pp-1γ1) Signaling2.5
13 Macrophage migration inhibitory factor (MIF) Signaling2.9
14 Hyaluronan synthase 2 Signaling2.6
15 Nucleosome assembly protein Chromosomal3.02.7
16 Histone H2a.z Chromosomal3.4
17 HMG-17 non-histone chromosomal protein Chromosomal2.8
18 APEX endonuclease DNA repair4.7
19 DNA polymerase α DNA replication3.82.9
20 Rb-binding protein (RBP1) Transcription3.73.1
21 Transcriptional regulatory factor (α-NAC) Transcription3.0
22 Transducin-like enhancer protein 4 (Grg-4) Transcription2.5
23 C-1 putative transcription factor Transcription2.6
24 Rat Y-Box binding protein α (RYB-α) Transcription2.7
25 Glutamine-rich factor 1 Transcription2.7
26 Small nuclear ribonucleoprotein Sm D3 RNA processing2.9
27 Heterogeneous nuclear ribonucleoprotein G RNA processing2.4
28 Splicing factor SC35 RNA processing2.9
29 Leucyl-tRNA synthetase homologue Protein synthesis2.9
30 Ribosomal phosphoprotein P1 Protein synthesis3.2
31 Ribosomal protein L5 Protein synthesis4.72.7
32 Ribosomal protein L6 Protein synthesis3.6
33 Ribosomal protein L7 Protein synthesis4.42.3
34 Ribosomal protein L7a Protein synthesis4.22.4
35 Ribosomal protein L9 Protein synthesis3.4
36 Ribosomal protein L10 Protein synthesis4.02.2
37 Ribosomal protein L12 Protein synthesis3.1
38 Ribosomal protein L19 Protein synthesis2.8
39 Ribosomal protein L21 Protein synthesis3.42.2
40 Ribosomal protein L22 Protein synthesis3.3
41 Ribosomal protein L23 Protein synthesis4.62.2
42 Ribosomal protein L26 Protein synthesis4.0
43 Ribosomal protein L27 Protein synthesis3.0
44 Ribosomal protein L30 Protein synthesis3.7
45 Ribosomal protein L32 Protein synthesis4.3
46 Ribosomal protein L35 Protein synthesis4.0
47 Ribosomal protein L41 Protein synthesis3.52.5
48 Ribosomal protein L44 Protein synthesis5.42.4
49 Ribosomal protein S4 Protein synthesis3.6
50 Ribosomal protein S7 Protein synthesis3.7
51 Ribosomal protein S9 Protein synthesis3.3
52 Ribosomal protein S12 Protein synthesis4.2
53 Ribosomal protein S13 Protein synthesis4.8
54 Ribosomal protein S15a Protein synthesis3.1
55 Ribosomal protein S16 Protein synthesis2.8
56 Ribosomal protein S18 Protein synthesis4.13
57 Ribosomal protein S19 Protein synthesis3.0
58 Ribosomal protein S20 Protein synthesis4.12.2
59 Ribosomal protein S23 Protein synthesis3.5
60 Elongation factor 2 (EF-2) Protein synthesis2.82.3
61 Signal recognition particle subunit (SRP) Protein synthesis4.92.2
62 Breast basic conserved protein 1 Protein synthesis4.5
63 RNA helicase p68 Protein synthesis3.9
64 Nucleophosmin (NPM; B23) Protein synthesis4.22.5
65 Spermidine synthase Protein/RNA synthesis3.7
66 Cyclophilin-40 (40 kD) Protein folding2.8
67 Cyclophilin (18 kD) Protein folding2.7
68 Ran/TC4 GTP-binding nuclear protein Protein/RNA transport2.9
69 Ran/TC4 binding protein (RanBP1) Protein/RNA transport3.2
70 Secretory carrier-associated protein 2 Protein transport3.2
71 Heat shock protein 60 (HSP60) d Protein folding5.0
72 Heat shock protein 90 (HSP90) Protein folding3.3
73 Chaperonin-containing TCP-1 zeta subunit Protein folding2.9
74 E2-EPF ubiquitin-carrier protein Protein degradation2.6
75 Ubiquitin-like protein SMT3B Protein degradation2.3
76 Ubiquitin Protein degradation4.2
77 R-IOTA (proteasome subunit) Protein degradation2.9
78 Phosphorylation regulatory protein HP-10 Protein phosphorylation2.6
79 Lactate dehydrogenase (LDH-A) d Metabolism3.1
80 Enolase-α Metabolism2.6
81 Glycerate dehydrogenase (GDH) Metabolism2.6
82 Thioredoxin Metabolism2.3