Table 3

Genes regulated by overexpressed c-Myca

No.Gene nameFunctionRatiob
c-mycTranscription4.5
1 PCAF associated factor-β Transcription2.3
2 DNA polymerase αc DNA synthesis3.6
3 Cyclin-dependent kinase-4 (cdk-4)d Cell cycle2.9
4 Centromere protein (27 kD) Cell cycle2.5
5 Phosphatidylinositol 4-phosphate 5-kinase Iα Signaling3.5
6 Sigma receptor type 1 (SigmaR1) Signaling2.6
7 Heparin-binding growth factor 8 (HBGF-8) Signaling2.4
8 Scavenger receptor class B type I (SR-B1) Metabolism2.5
9 Stearyl-CoA desaturase 2 Metabolism5.6
10 Thioredoxin-dependent peroxide reductasec Metabolism2.4
11 Fibrillin 2 Extracellular matrix2.4
12 PINCH proteinc Apoptosis0.32
13 GADD45d DNA repair0.45
14 Histone H3.3B Chromosomal0.37
15 HSP27 Protein folding0.46
16 Serine protease Protein degradation0.41
17 Ubiquitin-homology domain protein (PIC1) Protein degradation0.35
18 Peripheral-type benzodiazepine receptor Metabolism0.44
19 Drosophila frizzled gene homologue Signaling0.47
20 Nuclear dual-specificity phosphatase Signaling0.30
21 Prolactin receptor associated protein Signaling0.42
22 γ-PAK Signaling0.21
23 PAK-interacting exchange factor (β-PIX) Signaling0.23
24 PE31/TALLA Signaling0.35
25 Thy-I glycoproteinc Signaling0.41
26 Vascular endothelial growth factor D Signaling0.44
27 Channel integral membrane protein 28 Water channel0.37
28 Osteonectin Cell growth0.33
29 UP50 (EGF-like serum-suppressed gene) Cell growth0.34
30 TGF-β responsive adhesion-inhibition gene Tumor suppression0.29
31 Thrombospondind Metastasis0.23
32 Collagen α1(V) Cell structure0.32
  • a A complete list of the differentially expressed genes, including unknown ESTs, can be found on our web site (http://www-dcs.nci.nih.gov/research/labdata/Liulab.html).

  • b The average of ratios in comparison between WT+MYC and WT cells during log-phase growth. Values of more than 1 represent c-Myc up-regulated genes. Values of less than 1 represent the c-Myc down-regulated genes.

  • c Genes present in Tables 1 <$REFLINK> and 2 <$REFLINK> .

  • d Gene reported previously to be a Myc target.