Table 1

Methylationa of the p16 and MGMT genes in tumor/sputum pairs at time of diagnosis

CaseExposureSampleCytologyMethylation
p16MGMT
1Tobb/RadonSCCNAMU
SputumMild AtypiaMU
2Tob/RadonSCCNAUM
SputumSCCUM
3Tob/RadonSCCNAUM
SputumSCCUM
4TobSCCNAMM
SputumSCCMU
5TobSCCNAMM
SputumSCCMU
6Tob/RadonSCCNAMU
SputumMod. Dyspl.MU
7TobSCCNAMM
SputumMarked Dyspl.MM
8TobSCCNAMU
SputumMod. Dyspl.MM
9TobSCCNAMU
SputumMod. Dyspl.MU
10Tob/RadonSCCNAMM
SputumMarked Dyspl.MM
  • a Methylation state of the p16 and MGMT genes in tumors and sputa obtained at the time of diagnosis.

  • b Tob, tobacco; NA, not applicable; M, methylated; U, unmethylated; Mod. Dyspl., moderate dysplasia.