Table 2

Methylationa of the p16 and MGMT genes in sputum precedes clinical diagnosis of SCC

CaseExposureSampleMon prior to cancerCytologyMethylation
p16MGMT
1Tobb/RadonSCC0NAUM
Sputum5Mod. Dysp.MM
2Tob/RadonSCC0NAMM
Sputum5SuspiciousMM
Sputum5SuspiciousMM
Sputum5Marked Dysp.MM
3TobSCC0NAMM
Sputum6SCCMM
4Tob/RadonSCC0NAMU
Sputum10Mod. Dysp.MU
5Tob/RadonSCC0NAMM
Sputum8SuspiciousMM
Sputum13SuspiciousMM
6Tob/RadonSCC0NAMM
Sputum2SCCMM
Sputum9Mod. Dysp.MM
Sputum15Mild AtypiaMU
7Tob/RadonSCC0NAMM
Sputum5Mod. Dysp.MM
Sputum15Mod. Dysp.MM
8Tob/RadonSCC0NAMM
Sputum8SuspiciousMM
Sputum20SuspiciousMM
9Tob/RadonSCC0NAMU
Sputum0SCCMU
Sputum20CISMU
10TobSCC0NAMM
Sputum34Severe Dysp.MU
11TobSCC0NAMM
Sputum35Severe Dysp.MU
  • a Methylation state of the p16 and MGMT genes in tumors and sputa obtained from 11 different cases.

  • b Tob, tobacco; NA, not applicable; U, unmethylated; M, methylated; Mod. Dysp., moderate dysplasia; Suspicious, suspicious for malignancy; CIS, carcinoma in situ.