Table 2

Odds ratios and 95% confidence intervals of cervical carcinoma in situ in relation to HPV16 status

No. of cases/controlsOR (95% CI)a,b
HPV 16 status in the first smear
Age <25 years
Neg144 /2211 (Ref.)
Pos53 /155.4 (2.6–11.1)
Age 25–29 years
Neg99 /1681 (Ref.)
Pos47 /107.4 (3.1–17.9)
Age ≥30 years
Neg110 /1921 (Ref.)
Pos30 /115.3 (2.2–13.0)
Total483 /617cP = 0.434d
HPV 16 status in the last two smears before diagnosise
Neg-Neg108 /2351 (Ref.)
Pos-Neg26 /114.9 (2.1–11.3)
Neg-Pos54 /149.7 (4.3–21.8)
Pos-Pos75 /431.2 (10.6–91.8)
  • a Smears taken the last year before diagnosis have been excluded.

  • b OR, odds ratio; CI, confidence interval; Neg, negative; Pos, positive; Ref, within reference values.

  • c One risk set (including one case and two controls) was not included because of missing information on HPV status.

  • d Test for interaction by age.

  • e Only analyzed for women with 2 or more smears.