Table 3

Subset of genes differentially expressed in ovarian tumors compared with nonmalignant ovarian samples

TagGeneExpressionaFunction
FoldOSE ML10Ovarian tumorsColon epitheliumColon tumors
Up-regulatedb
GGGCATCTCTHLA-DR α chain289++MHC, class II/antigen presentation
TTTGGGCCTACysteine-rich protein 1123+++LIM/double zinc finger
ATCGTGGCGGClaudin 4109++++Tight junction barrier function
TATTATGGTAESTs101+Unknownc
GCCTACCCGASurface marker 1/GA733-1/TROP293+Tumor Agc/Ca2+
CTCGCGCTGGClaudin 383++++Tight junction barrier function
TTGCTTGCCACeruloplasmin (ferroxidase)79+Secreted metalloprotein/antioxidant
CCTGCTTGTCHE472+++Secreted protease inhibitor
AGGGAGGGGCGlutathione peroxidase 3 (plasma)69+Secreted selenoprotein/peroxidase
TGTGGGAAATSecretory leukocyte protease inhibitor60++Secreted serine protease inhibitor
CCTGATCTGCESTs56+Unknown
ACCATTGGATIFN-induced transmembrane protein 149+++Receptor for IFN signaling
AGTTTGTTAGEp-CAM/EGP2/TROP1/GA733-248++++Tumor Ag/Ca-independent CAM/proliferation
CCTGGGAAGTMucin 143++++Tumor Ag/type-I membrane glycoprotein
CAACTAATTCApoJ/clusterin39++Secreted chaperone/cytoprotection
GCCTGCAGTCSerine protease inhibitor, Kunitz type 234+++++Transmembrane/protease inhibitor
CGACCCCACGApoE34++Lipoprotein particle binding, internalization, and catabolism
TTCTGTGCTGComplement component 1, r subcomponent24+Serine protease of complement system/autoimmune diseases
CGCCGACGATG1P3/IFI-6-1624++++IFN primary response/α-IFN-inducible
CCCGCCCCCGLutheran blood group protein/BCAM17++Possible cell surface receptor/immunoglobulin superfamily
GATCAGGCCAUnknown16+++Unknown
GTGGAAGACGMal16+Trans-Golgi membrane protein (epithelial cells)/T-cell differentiation
GATGAGGAGAESTs13++++Unknown
TTCCCTTCTTHLA-DPB113+MHC, class II/antigen presentation
CCCCCTGCAGMesothelin12++GPI-anchored/mesothelioma and ovarian cancer antigen/cell adhesion
TGCTGCCTGTBone marrow stroma antigen 2/BST-212+++Type II transmembrane protein/pre-B-cell growth
TGCAGCACGAHLA-Cw10+++++MHC, class I/antigen presentation
Down-regulatedd
GGTTATTTTGUnknown99+Unknown
TGTCATCACALysyl oxidase-like 273+Secreted/collagen and elastin cross-linker
AAAATAAACAChloride intracellular channel 4 like29+Ion transport
TAAAAATGTTPlasminogen activator inhibitor, type 126++Serine protease inhibitor family/tPA inhibitor
GAGCTTTTGAEST14+Unknown
GGCTGATGTGGlycine t-RNA synthetase13+Protein synthesis
CGACGAGGAGEpithelial membrane protein-313+Proliferation, differentiation, and apoptosis
GCCCCCAATAGalectin-110+++β-Galactoside binding lectin/ECM interaction and proliferation
GCAACTTGGAVinexin β10+Cell adhesion and cytoarchitecture
  • a Expression is defined as: −, 0–9 tags/100,000; +, 10–49 tags/100,000; ++, >49 tags/100,000.

  • b Candidates up-regulated at least 30-fold in tumors.

  • c Ag, antigen; CAM, cellular adhesion molecule; BCAM, basal cell adhesion molecule; GPI, glycosylphosphatidyl inositol; tPA, tissue plasminogen activator; ECM, extracellular matrix. IFN, interferon.

  • d Candidates down-regulated at least 10-fold in tumors.