Table 1

Effect of celecoxib on body weights in male F344 rats

Experimental groupNo. of rats/groupIndividual body weightsa (g) at weekb
0471523394752
AOM-treated rats
Control diet (AIN-76A)36119 ± 10225 ± 11267 ± 12345 ± 15385 ± 22447 ± 23460 ± 34462 ± 30
Celecoxib, 500 ppmc36113 ± 10224 ± 11270 ± 13345 ± 18386 ± 19443 ± 29463 ± 27468 ± 24
Celecoxib, 1000 ppmc36114 ± 11227 ± 11274 ± 13349 ± 17391 ± 19451 ± 25465 ± 31469 ± 32
Celecoxib, 1500 ppmc36114 ± 11227 ± 11274 ± 12347 ± 17384 ± 19444 ± 24461 ± 23464 ± 28
Celecoxib, 1500 ppmd36114 ± 11226 ± 13269 ± 15340 ± 19387 ± 22451 ± 25470 ± 32471 ± 31
Saline-treated rats
Control diet6117 ± 4237 ± 10283 ± 13364 ± 22439 ± 28466 ± 32478 ± 35481 ± 34
Celecoxib, 1500 ppmc6116 ± 5237 ± 14284 ± 19361 ± 23435 ± 30471 ± 34487 ± 36489 ± 32
  • a Values represent the mean ± SD.

  • b Weeks after the last AOM or saline injection.

  • c Celecoxib was administered in diet beginning 2 weeks before and during carcinogen treatment and until termination of the study at week 52.

  • d Celecoxib was administered in the diet starting 14 weeks after the second AOM treatment and until termination of the study at 52 weeks.