Table 1

Effect of celecoxib on body weights in male F344 rats

Experimental group	No. of rats/group	Individual body weights^a (g) at week^b
Experimental group	No. of rats/group	0	4	7	15	23	39	47	52
AOM-treated rats
Control diet (AIN-76A)	36	119 ± 10	225 ± 11	267 ± 12	345 ± 15	385 ± 22	447 ± 23	460 ± 34	462 ± 30
Celecoxib, 500 ppm^c	36	113 ± 10	224 ± 11	270 ± 13	345 ± 18	386 ± 19	443 ± 29	463 ± 27	468 ± 24
Celecoxib, 1000 ppm^c	36	114 ± 11	227 ± 11	274 ± 13	349 ± 17	391 ± 19	451 ± 25	465 ± 31	469 ± 32
Celecoxib, 1500 ppm^c	36	114 ± 11	227 ± 11	274 ± 12	347 ± 17	384 ± 19	444 ± 24	461 ± 23	464 ± 28
Celecoxib, 1500 ppm^d	36	114 ± 11	226 ± 13	269 ± 15	340 ± 19	387 ± 22	451 ± 25	470 ± 32	471 ± 31
Saline-treated rats
Control diet	6	117 ± 4	237 ± 10	283 ± 13	364 ± 22	439 ± 28	466 ± 32	478 ± 35	481 ± 34
Celecoxib, 1500 ppm^c	6	116 ± 5	237 ± 14	284 ± 19	361 ± 23	435 ± 30	471 ± 34	487 ± 36	489 ± 32

a Values represent the mean ± SD.
b Weeks after the last AOM or saline injection.
c Celecoxib was administered in diet beginning 2 weeks before and during carcinogen treatment and until termination of the study at week 52.
d Celecoxib was administered in the diet starting 14 weeks after the second AOM treatment and until termination of the study at 52 weeks.