Incidence and patterns of APC and β-catenin gene mutations and the statusa of β-catenin protein localization in lung lesions induced
| No. of samples | Incidence and patterns of mutationsb | Location of β-catenin protein | |||
|---|---|---|---|---|---|
| APC | β-catenin | ||||
| Adenomas | (2/15; 13.3%) | (3/15; 20.0%) | |||
| 3 | 515 GCT to CGT (Ala to Arg) | Cytoplasm | |||
| 4 | 679 TGT to TGC (Cys to Cys) | Mc | Cell membrane | ||
| 9 | 32 GAT to GTT (Asp to Val) | M | Nucleus and cytoplasm | ||
| 10 | 34 GGA to GAA (Gly to Glu) | M | Cytoplasm | ||
| 12 | 32 GAT to GTT (Asp to Val) | M | Nucleus and cytoplasm | ||
| Adenocarcinomas | (8/20;40.0%) | (5/20; 25.0%) | |||
| 1 | 292 GAA to AAA (Glu to Lys) | Cytoplasm | |||
| 415 TGC to TGT (Cys to Cys) | M | ||||
| 2 | 469 GGG to AGG (Gly to Arg) | M | Nucleus and cytoplasm | ||
| 3 | 819 GTT to GTC (Val to Val) | S | Nucleus and cytoplasm | ||
| 1392 AGT to AAT (Ser to Asn) | M | ||||
| 5 | 1422 GAC to GGC (Asp to Gly) | M | 35 ATC to GTC (lle to Val) | M | Nucleus and cytoplasm |
| 6 | 298 GCT to GCC (Ala to Ala) | S | Cell membrane | ||
| 8 | 591 TGG to TGA (Trp to Stop) | N | Nucleus and cytoplasm | ||
| 10 | 32 GAT to GTT (Asp to Val) | M | Nucleus and cytoplasm | ||
| 11 | 33 TCT to TTT (Ser to Phe) | M | Nucleus and cytoplasm | ||
| 13 | 32 GAT to GTT (Asp to Val) | M | Nucleus and cytoplasm | ||
| 16 | 440 GTT to ATT (Val to lle) | M | Cytoplasm | ||
| 17 | 41 ACC to ATC (Thr to IIe) | M | Nucleus and cytoplasm | ||
| 20 | 817 ATG to GTG (Met to Val) | M | Cytoplasm | ||
a Staining patterns were divided into three groups: cell membrane, cytoplasm, and nucleus and cytoplasm.
b codons, base substitutions, and amino acid alterations.
c Type of mutation: M, missense mutation; S, silent mutation; N, nonsense mutation.