Table 1

Inhibition of cell growth (GI50) and HGF/SF-mediated plasmin activation (IC50) by geldanamycin analogues

Geldanamycin National Service Center no.GI50 (m)IC50 (m)
3208774.99 × 103.04 × 10
2551053.11 × 105.52 × 10
255109a4.90 × 101.13 × 10
122750a3.91 × 102.83 × 10
3305076.88 × 101.35 × 10
2551041.02 × 102.38 × 10
3304993.04 × 106.67 × 10
3305127.92 × 106.01 × 10
3305004.23 × 101.05 × 10
2654827.82 × 102.61 × 10
2551123.00 × 106.84 × 10
2551103.00 × 107.84 × 10
  • a Compounds initially identified from the screen.