Table 4

Associations of UGT1A1 genotypes and bilirubin levels with severe toxicity

Leukopenia (grade 4) and/or diarrhea (grade 3 or worse)a
Experienced (n = 26)Not experienced (n = 92)P
UGT1A1*28 b <0.001c
−/−14 (54%)79 (86%)
+/−8 (31%)10 (11%)
+/+4 (15%)3 (3%)
UGT1A1*6 b >0.2c
−/−22 (85%)69 (75%)
+/−4 (15%)21 (23%)
+/+0 (0%)2 (2%)
Total bilirubin levels (μmol/l)
Prior to therapy8.6 (6.8–13.7)d8.6 (6.8–12.0)e>0.2f
Highest after infusion16.2 (11.8–26.5)13.7 (10.3–18.8)e0.071f
  • a Japan Society for Cancer Therapy criteria.

  • b Symbols of (−/−), (+/−), and (+/+) denote homozygous absence of the variant allele, heterozygous, and homozygous for the variant allele, respectively.

  • c GENEPOP version 3.1d software, the Laboratoire de Génétique et Environment, Montpellier, France.

  • d Median (interquantile range).

  • e One patient missed the bilirubin measurement during the treatment.

  • f Mann-Whitney U test.