Table 5

Association of UGT1A1 genotypes with total bilirubin levels in 115 patients

GenotypesanTotal bilirubin levels (μmol/l)b
TATA box UGT1A1*28Codon 71 UGT1A1*6Codon 229 UGT1A1*27Prior to therapyHighest after infusion
−/−−/−−/−678.6 (6.8–12.0)13.7 (10.3–17.1)
−/−+/−, +/+c−/−2510.3 (8.6–13.7)15.4 (11.1–25.7)
+/−−/−−/−, +/−d168.6 (6.8–10.3)18.0 (12.0–23.1)
+/+−/−−/−, +/−e712.0 (6.8–20.5)34.2 (22.2–42.8)
  • a Symbols of (−/−), (+/−), and (+/+) denote homozygous absence of the variant allele, heterozygous, and homozygous for the variant allele, respectively.

  • b Median (interquantile range).

  • c Two patients homozygous for UGT1A1

  • * 6 had bilirubin levels of 23.9 and 11.8 prior to therapy and 18.8 and 23.9 following initiation of therapy, respectively.

  • d One patient who had both UGT1A1

  • * 28 and >UGT1A1

  • * 27 had bilirubin levels of 13.7 prior to therapy and 17.1 after initiation of therapy, respectively.

  • e Two patients homozygous for UGT1A1

  • * 28 and heterozygous for UGT1A1

  • * 27 had bilirubin levels of 10.3 and 44.5 prior to therapy and 47.9 and 42.8 after initiation of therapy, respectively.