Table 1

The effects of 5% dietary PEG (Mr 8000) on intestinal tumors in Min mice

DietSexGenotype Apc(+/−) Msh (as noted)Small intestinal tumorsa (95% CI)Cecal tumorsa (95% CI)Colon tumorsa (95% CI)Animals with colon tumors/total animalsb
ControlMale Msh2(+/−) 21.3 (1.2–65.9)0.25 (0.2–2.2)0.00 /2
Msh2(+/+) 5.4 (0.16–18)0.00.00 /3
Female Msh2(+/−) 7.8 (3.4–14.0)0.1 (0.006–0.6)0.0a (0.0–0.0)0 /6
Msh2(+/+) 14.5 (6.8–25.3)0.02 (0.02–0.2)0.08a (0.006–0.4)2 /7
PEGMale Msh2(+/−) 19.00.00.00 /1
Msh2(+/+) 8.6 (3.0–17.1)0.1 (0.006–0.6)0.2 (0.2–1.9)1 /6
Female Msh2(+/−) 12.2 (6.7–19.2)0.1 (0.01–0.6)1.3b (0.3–3.0)5 /7
Msh2(+/+) 13.5 (7.3–21.6)0.02 (0.01–0.1)1.3b (0.3–3.1)6 /8
  • a Values are the average number of tumors per animal with 95% CI. Within a column, numbers sharing a common letter are not significantly different from each other as determined by analysis of variance (P ≥ 0.05). Numbers not sharing a common letter are significantly different from one another.

  • b Logistic analysis shows that the effect of genotype is not significant (P = 0.27), diet is significant (P < 0.001), and so is sex (P < 0.001).