Table 2

Cox multivariate analysis of RFS and OS in 2780 patients

FactorRFSOS
RHRaPRHRaP
Basic model
Age and menopausal statusb<0.0001<0.0001
Age premenopausalc0.68 (0.60–0.77)0.75 (0.65–0.88)
Age postmenopausalc0.94 (0.84–1.00)1.24 (1.13–1.35)
Post- vs. premenopausal1.43 (1.16–1.77)1.35 (1.05–1.74)
Tumor size<0.0001<0.0001
2–5 cm vs. ≤2 cm1.43 (1.26–1.62)1.45 (1.26–1.67)
>5 cm vs. ≤2 cm1.85 (1.53–2.24)1.87 (1.53–2.29)
Nodal status<0.0001<0.0001
N1–3 vs. N02.02 (1.72–2.37)2.08 (1.75–2.47)
N>3 vs. N03.75 (3.22–4.36)3.53 (2.99–4.17)
Grade<0.0001<0.005
Moderate vs. poor0.72 (0.62–0.85)0.74 (0.62–0.88)
Well vs. poor0.61 (0.34–1.08)0.65 (0.36–1.19)
Missing vs. poor0.73 (0.56–0.96)0.91 (0.78–1.05)
Adjuvant therapy (yes vs. no)0.61 (0.52–0.71)<0.00010.76 (0.64–0.89)<0.001
ER/PgR statusd0.42<0.0001
+/− vs.−/−0.97 (0.79–1.19)0.82 (0.66–1.01)
−/+ vs. −/−0.81 (0.61–1.08)0.63 (0.46–0.86)
+/+ vs.−/−0.91 (0.79–1.06)0.63 (0.54–0.74)
Missing vs. −/−0.80 (0.58–1.10)0.65 (0.47–0.90)
Additions to basic model:
+uPAe,f<0.0001<0.0001
Intermediate vs. low1.29 (1.10–1.52)1.37 (1.15–1.64)
High vs. low1.93 (1.64–2.28)2.15 (1.79–2.59)
+uPARe,g<0.0001<0.0001
Intermediate vs. low1.10 (0.95–1.28)1.01 (0.85–1.19)
High vs. low1.36 (1.17–1.59)1.32 (1.12–1.56)
+PAI-1e,h<0.0001<0.0001
Intermediate vs. low1.50 (1.31–1.71)1.43 (1.23–1.66)
High vs. low2.52 (2.06–3.08)2.64 (2.13–3.26)
+PAI-2e,i0.100.99
Intermediate vs. high1.12 (0.99–1.27)1.00 (0.88–1.15)
Low vs. high1.24 (0.99–1.57)0.99 (0.76–1.29)
  • a Numbers in parentheses, 95% CI.

  • b Age and menopausal status (at surgery) combined.

  • c Age in decades tested separately for pre- and postmenopausal patients.

  • d Cut points used: 10 fmol/mg of protein for both.

  • e Added separately to the basic multivariate model.

  • f Low, ≤0.19 (n = 560); intermediate, >0.19 and ≤1.21 (n = 1313); high, >1.21 ng/mg of protein (n = 907).

  • g Low, ≤0.57 (n = 663); intermediate, >0.57 and ≤1.13 (n = 1100); high, >1.13 ng/mg of protein (n = 1017).

  • h Low, ≤9.33 (n = 815; intermediate, >9.33 and ≤45.28 (n = 1731); high, >45.28 ng/mg of protein (n = 229).

  • i Low, ≤0.62 (n = 165); intermediate, >0.62 and ≤4.05 (n = 1804); high, >4.05 ng/mg of protein (n = 811).