Table 3

Cox multivariate analysis in all patients and in nodal subgroups of patients

FactoraRFSOS
RHRbPRHRbP
All patients:
+uPA<0.0001<0.0001
Intermediate vs. low1.22 (1.02–1.45)1.32 (1.08–1.61)
High vs. low1.69 (1.39–2.05)1.92 (1.54–2.38)
+PAI-1<0.0001<0.0001
Intermediate vs. low1.32 (1.14–1.54)1.18 (0.99–1.40)
High vs. low2.17 (1.74–2.70)2.00 (1.58–2.55)
+PAI-2<0.00010.02
Intermediate vs. high1.30 (1.14–1.48)1.16 (1.01–1.33)
Low vs. high1.76 (1.38–2.24)1.43 (1.09–1.89)
Node-negative patients:
+uPA<0.0001<0.0001
Intermediate vs. low1.31 (0.98–1.76)1.46 (1.03–2.07)
High vs. low2.02 (1.47–2.77)2.45 (1.67–3.59)
+PAI-1<0.0020.003
Intermediate vs. low1.34 (1.04–1.73)1.09 (0.81–1.47)
High vs. low2.03 (1.39–2.97)1.71 (1.13–2.61)
+PAI-2<0.0001<0.05
Intermediate vs. high1.45 (1.17–1.81)1.19 (0.93–1.52)
Low vs. high2.57 (1.71–3.86)1.89 (1.16–3.10)
Node-positive patients:
+uPA<0.001<0.0001
Intermediate vs. low1.18 (0.94–1.47)1.27 (1.00–1.61)
High vs. low1.52 (1.19–1.94)1.72 (1.32–2.24)
+PAI-1<0.0001<0.0001
Intermediate vs. low1.34 (1.11–1.63)1.23 (1.00–1.52)
High vs. low2.26 (1.72–2.98)2.13 (1.59–2.86)
+PAI-2<0.0020.20
Intermediate vs. high1.23 (1.04–1.45)1.15 (0.97–1.36)
Low vs. high1.47 (1.09–1.99)1.26 (0.90–1.75)
  • a Low, intermediate, and high for the respective factors; see legend to Table 2 <$REFLINK> .

  • b Numbers in parentheses, 95% CI; corrected for the basic model including age and menopausal status, tumor size and grade, nodal status, adjuvant therapy, and ER/PgR status. For node-positive patients, nodal status was included as N>3 vs. N1–3; for node-negative patients, nodal status and adjuvant therapy were not applicable.