Table 1

IC50 values of indolocarbazole compounds against selected kinases.

Assays were performed as described in “Materials and Methods” for Chk1, by Meijer and Kim (39) for cdc2, and by Chan et al. (40) for PKC. IC50 values were determined by nonlinear regression using Kaleidagraph.

IC50m)
Chk1cdc2PKC
SB-2180780.0150.251
Staurosporine0.0080.0060.005
UCN-010.0070.10.004a
  • a From Takahashi et al. (41) .