Comparison of the therapeutic effects of ONYX-015 and RT against isogenic RKO and RKO.p53.13 tumors
| Treatment groupa | Average tumor growth delay (days)b | Percentage tumor-free at 90 days posttreatment |
|---|---|---|
| RKO | ||
| PBS | NA | 0 (0/9) |
| 20 Gy | 16c | 0 (0/9) |
| ONYX-015 | 1 | 0 (0/9) |
| ONYX-015+ 20 Gy | 17c | 0 (0/9) |
| RKO.p53.13 | ||
| PBS | NA | 0 (0/9) |
| 20 Gy | 22c | 0 (0/9) |
| ONYX-015 | 19c | 11 (1/9) |
| ONYX-015+ 20 Gy | 48d | 33 (3/9) |
a i.m. tumors were injected with either PBS or ONYX-015 (108 pfu) for 5 consecutive days (days 0–4). A single dose of 60Co γ-radiation was administered on day 5.
b Average time to reach 1000 mm3 relative to PBS-injected controls. NA, not applicable.
c Statistically significant difference from PBS-injected controls (P < 0.001) as determined by ANOVA.
d Statistically significant difference from ONYX-015- and RT-treated groups (P < 0.001) as determined by ANOVA.