Table 1

Comparison of the therapeutic effects of ONYX-015 and RT against isogenic RKO and RKO.p53.13 tumors

Treatment groupaAverage tumor growth delay (days)bPercentage tumor-free at 90 days posttreatment
RKO
PBSNA0 (0/9)
20 Gy16c0 (0/9)
ONYX-01510 (0/9)
ONYX-015+ 20 Gy17c0 (0/9)
RKO.p53.13
PBSNA0 (0/9)
20 Gy22c0 (0/9)
ONYX-01519c11 (1/9)
ONYX-015+ 20 Gy48d33 (3/9)
  • a i.m. tumors were injected with either PBS or ONYX-015 (108 pfu) for 5 consecutive days (days 0–4). A single dose of 60Co γ-radiation was administered on day 5.

  • b Average time to reach 1000 mm3 relative to PBS-injected controls. NA, not applicable.

  • c Statistically significant difference from PBS-injected controls (P < 0.001) as determined by ANOVA.

  • d Statistically significant difference from ONYX-015- and RT-treated groups (P < 0.001) as determined by ANOVA.