Table 1

Demographic data on prostate cancer families screened for BRCA1 and BRCA2 mutations

Family no.Family members screenedAge of onsetNo. of prostate affected/average age of onset (yr)Additional breast/ovarian cancersaAdditional cancersa
1Proband635 /71.21 BrBo, Ga, Li, My, Pa, Sk, St
Breast-sister60
2Proband664 /69.51 Br, 1 male Br, 1 OvNone
Prostate-nephew56
3Probandn/a8 /69.75 Br, 1 male Br, 1 OvOt
Prostate75
4Proband618 /70.41 BrLe, Sk
Breast-cousinn/a
5Proband656 /67.81 BrLi
Breast-sistern/a
6Proband655 /67.21 BrBo, Lu, Ot, Sk
Breast-sister67
7Proband707 /62.51 BrLe, Ot, Re, St
Breast-sister62
8Proband654 /66.51 BrMe, 2 Ot
Breast-sister73
9Proband577 /62.12 BrNone
Prostate59
10Proband748 /672 Br2 Ot
Prostate64
11Proband767 /67.22 BrLi
Prostate69
12Proband684 /66.52 BrNone
Prostate65
13Proband655 /68.82 BrIn, Te, Thy
Prostate72
14Proband574 /622 Br, 1 male Br, 1 PrNone
Prostate56
15Proband683 /71.32 BrNone
Prostate77
16Proband683 /61.71 BrLi
Prostate59
17Proband673 /703 BrBo, Co, 2 Lu, 2 Ot, Thy
Prostate73
18Proband623 /59.72 BrBn, 2 Lu
19Proband693 /75.32 BrCo
Prostate82
20Proband603 /64.72 BrThy
Prostate79
21Proband703 /632 BrMe, 4 Ot
Prostate71
22Proband653 /69.31 Br, 1 OvMe
Prostate69
  • a Cancers include: Bo, bone; Bn, brain; Br, breast; Co, colon; Ga, gallbladder; In, intestine; Le, leukemia; Li, liver; Lu, lung; Me, melanoma; My, myeloma; Ot, other; Ov, ovarian; Pa, pancreas; Pr, prostate; Re, rectum; Sk, skin; St, stomach; Te, testes; Th, throat; Thy, thyroid.