Table 1

Demographic data on prostate cancer families screened for BRCA1 and BRCA2 mutations

Family no.	Family members screened	Age of onset	No. of prostate affected/average age of onset (yr)	Additional breast/ovarian cancers^a	Additional cancers^a
1	Proband	63	5 /71.2	1 Br	Bo, Ga, Li, My, Pa, Sk, St
	Breast-sister	60
2	Proband	66	4 /69.5	1 Br, 1 male Br, 1 Ov	None
	Prostate-nephew	56
3	Proband	n/a	8 /69.7	5 Br, 1 male Br, 1 Ov	Ot
	Prostate	75
4	Proband	61	8 /70.4	1 Br	Le, Sk
	Breast-cousin	n/a
5	Proband	65	6 /67.8	1 Br	Li
	Breast-sister	n/a
6	Proband	65	5 /67.2	1 Br	Bo, Lu, Ot, Sk
	Breast-sister	67
7	Proband	70	7 /62.5	1 Br	Le, Ot, Re, St
	Breast-sister	62
8	Proband	65	4 /66.5	1 Br	Me, 2 Ot
	Breast-sister	73
9	Proband	57	7 /62.1	2 Br	None
	Prostate	59
10	Proband	74	8 /67	2 Br	2 Ot
	Prostate	64
11	Proband	76	7 /67.2	2 Br	Li
	Prostate	69
12	Proband	68	4 /66.5	2 Br	None
	Prostate	65
13	Proband	65	5 /68.8	2 Br	In, Te, Thy
	Prostate	72
14	Proband	57	4 /62	2 Br, 1 male Br, 1 Pr	None
	Prostate	56
15	Proband	68	3 /71.3	2 Br	None
	Prostate	77
16	Proband	68	3 /61.7	1 Br	Li
	Prostate	59
17	Proband	67	3 /70	3 Br	Bo, Co, 2 Lu, 2 Ot, Thy
	Prostate	73
18	Proband	62	3 /59.7	2 Br	Bn, 2 Lu

19	Proband	69	3 /75.3	2 Br	Co
	Prostate	82
20	Proband	60	3 /64.7	2 Br	Thy
	Prostate	79
21	Proband	70	3 /63	2 Br	Me, 4 Ot
	Prostate	71
22	Proband	65	3 /69.3	1 Br, 1 Ov	Me
	Prostate	69

a Cancers include: Bo, bone; Bn, brain; Br, breast; Co, colon; Ga, gallbladder; In, intestine; Le, leukemia; Li, liver; Lu, lung; Me, melanoma; My, myeloma; Ot, other; Ov, ovarian; Pa, pancreas; Pr, prostate; Re, rectum; Sk, skin; St, stomach; Te, testes; Th, throat; Thy, thyroid.