Table 3

c-erbB-4 nuclear immunoreactivity (defined as negative or <25% of nuclei positive versus ≥25% nuclei positive) compared with other parameters

Parameterχ2P
Gradea13.460.0012
Histological typeb0.390.53
Nodal Statusc0.180.67
ER statusc0.720.40
EGFR positivityd4.570.033
c-erbB-2 positivityd0.300.59
c-erbB-3 positivityd3.850.05
Amphireguline7.440.0064
Criptoe8.480.0036
TGF-αf1.670.02
  • a Infiltrating ductal carcinoma grade I versus II versus III.

  • b Infiltrating ductal versus lobular carcinoma.

  • c Positive versus negative.

  • d Present or absent.

  • e Grouped as 0–3 versus 4–5.

  • f Grouped as 0–5 versus 6–7.