Table 1

The effects of GM analogues on protein down-regulation and cell growth

DrugaMCF-7SKBR-3 IC50c (growth inh.) (nm)
IC50b (HER-2) (nm)IC50b (Raf-1) (nm)IC50c (growth inh.) (nm)
GM (○)45200253
GMD-4c (○—○4)60220010020
GMD-7c (○—○7)70500600200
GMD-9c (○—○9)5003800700500
GMD-12c (○—○12)7503500700650
ButylaminoGM (○—4)80350600350
GM-quinone (○—□4)5535035060
GMD-a (○—〈4)5003500650250
GMD-aa (〉—〈4)>5000>5000>2000>2000
  • a See Fig. 1 <$REFLINK> for the structure of each drug.

  • b MCF-7 cells were treated with various concentrations of each drug; IC50 for each protein is designated as the amount of each drug needed to decrease the steady-state level of either HER2 or Raf-1 to 50% of the control after 24 h of treatment.

  • c MCF-7 and SKBR-3 cells were treated with different concentrations of each drug for 4 days; IC50 is designated as the amount of each drug needed to inhibit cell growth by 50% compared with the control after the 4-day treatment. The numbers were the average of three different experiments.