Table 2

Effects of celecoxib and ibuprofen on the incidence, growth, and development of DMBA-induced rat mammary tumors

Treatment groupaLatency (days)Incidence (%)Tumor burdendTumor volume (cc)e
CancerbAll tumorsc
Control581001003.2 ± 0.21.5 ± 0.4
Ibuprofen86f60 (40)f60 (40)f1.5 ± 0.3 (52)f0.6 ± 0.2 (57)f
Celecoxib95f32 (68)f40 (60)f0.4 ± 0.1 (86)f0.3 ± 0.1 (81)f
  • a Forty rats/treatment group were fed the control diet supplemented in the experimental diets with 1500 ppm of either ibuprofen or celecoxib.

  • b Cancer incidence is the frequency of animals that developed breast cancer.

  • c The incidence of all tumors includes three animals in the celecoxib treatment group that developed fibroadenomas.

  • d Mean number of tumors/animal ± SE.

  • e Mean tumor volume ± SE.

  • f Statistical significance relative to the control group at P < 0.001. Reductions in the incidence rates, tumor burden, and tumor volume for the experimental diets relative to the control diet are given in parentheses.